a Record control number WOS:000341845100006

a ISSN 0008-4212

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QP356.3

b Item number .A28 2014

a Personal name Altinbas, Burcin.

h Medium Electronic Document

a Title Activation of the central histaminergic system mediates arachidonic-acid-induced cardiovascular effects

c Statement of responsibility, etc Burçin Altınbaş, Bora Burak Topuz, Tuncay İlhan, Mustafa Sertaç İlhan, Hatice Erdost, Murat Yalçın.

b Name of publisher, distributor, etc Canadıan Scıence Publıshıng,

c Date of publication, distribution, etc 2014.

a Summary, etc The aim of this study was to explain the involvement of the central histaminergic system in arachidonic acid (AA)-induced cardiovascular effects in normotensive rats using hemodynamic, immunohistochemistry, and microdialysis studies. Intracerebroventricularly (i.c.v.) administered AA (0.25, 0.5, and 1.0 mu mol) induced dose-and time-dependent increases in mean arterial pressure and decreased heart rate in conscious normotensive Sprague-Dawley rats. Central injection of AA (0.5 mu mol) also increased posterior hypothalamic extracellular histamine levels and produced strong COX-1 but not COX-2 immunoreactivity in the posterior hypothalamus of rats. Moreover, the cardiovascular effects and COX-1 immunoreactivity in the posterior hypothalamus induced by AA (0.5 mu mol; i.c.v.) were almost completely blocked by the H2 receptor antagonist ranitidine (50 and 100 nmol; i.c.v.) and partially blocked by the H1 receptor blocker chlorpheniramine (100 nmol; i.c.v.) and the H3-H4 receptor antagonist thioperamide (50 and 100 nmol; i.c.v.). In conclusion, these results indicate that centrally administered AA induces pressor and bradycardic responses in conscious rats. Moreover, we suggest that AA may activate histaminergic neurons and increase extracellular histamine levels, particularly in the posterior hypothalamus. Acting as a neurotransmitter, histamine is potentially involved in AA-induced cardiovascular effects under normotensive conditions.

a Topical term or geographic name as entry element Brain microdialysis

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Main entry heading Canadıan Journal of Physıology and Pharmacology

g Relationship information Aug 2014, Vol.92, Issue:8, p.645-654

x International Standard Serial Number 00084212

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1139/cjpp-2014-0043